Abstract
Objective To identify links between neurophysiological and functional outcome measures in ALS. Methods Clinical function was assessed in 53 ALS patients (age 54 ± 10.3 years) via ALSFRS-r scale, hand grip strength and Forced Vital capacity (FVC). Compound muscle action potential (CMAP) amplitude, F-wave persistence, neurophysiological index (NI) were measured from the ulnar nerve, recording at the Abductor Digiti Minimi (ADM) muscle. Results The total ALSFRS-r scale demonstrated moderate positive correlations with CMAP amplitude (r = .354, p = .016), F-wave persistence (r = .362, p = .014) and NI (r = .431, p = .003). Measures of neurophysiological function were strongly positively correlated with the fine-motor subscale of the ALSFRS-r scale (CMAP r = .579, p .001, NI r = .579, p .001). Average grip strength showed a strong positive correlation with CMAP amplitude (r = .553, p .001), and NI (r = .570, p .001), and a moderate positive correlation with F-wave persistence (r = .300, p = .040). FVC demonstrated a moderate positive correlation with CMAP amplitude (r = .302, p = .041), and NI (r = .386, p = .008). Conclusions Neurophysiological measures correlate with functional outcomes in ALS, specifically those relating to fine-motor function. Significance Identifying links between objective neurophysiological markers and patient reported outcomes are important to assess the impact of clinical interventions.
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