Abstract
The effect of the selective Na +/H + antiporter inhibitor 5-( N-ethyl- N-isopropyl)-amiloride (EIPA) on amino acid release from the ischemic/reperfused rat cerebral cortex was investigated using a cortical cup technique. EIPA (25 μM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia–reperfusion evoked efflux of aspartate, glutamate, γ-aminobutyric acid, taurine and phosphoethanolamine. Reductions in the ischemia-evoked releases of these amino acids suggest that ischemia precipitates acidosis, Na +/H + exchange and cell swelling with amino acid release as the cells mount a regulatory volume decrease response. EIPA, by blocking Na +/H + exchange, would reduce cell swelling and the resulting amino acid release.
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