Abstract
Publisher Summary This chapter focuses on characteristics of platelet-derived growth factor (PDGF)-binding proteins and factors that affect PDGF-binding protein complexes, identification of specific binding proteins by various assays, and limitations in the analysis of the functional role of these binding proteins. PDGF is a potent mitogen for connective tissue cells, which was discovered because of the ability of platelets to reconstitute the mitogenic activity of whole blood serum lacking in serum derived from cell-free plasma. Release of PDGF and other mitogens from platelet α-granules is dependent on platelet activation, and it has been postulated that focal release of PDGF at sites of injury may play a physiological role in wound healing and tissue repair and a pathological role in the formation of lesions of atherosclerosis characterized by smooth muscle cell proliferation. The possible importance of focal release of PDGF and local PDGF concentrations at the site of release is suggested by in vivo clearance studies with purified and 125 I-labeled PDGF.
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