Abstract
Increased sensitivity to audiogenic seizures by reserpine was antagonized by 5-hydroxytryptophan (5HTP). The antagonism was dependent upon the conversion of 5HTP to 5 hydroxytryptamine (5HT) in brain since blockade of both cerebral and extracerebral decarboxylase prevented the 5HTP effect, whereas selective blockade of extracerebral decarboxylase did not affect the 5HTP antagonism. Increased seizure susceptibility occurred when brain concentrations of 5HT were decreased, while decreased susceptibility occurred when brain concentrations of 5HT were elevated. 5HTP did not alter norepinephrine or dopamine concentrations in brain. The results of this study indicate that 5HT plays a role in modulating audiogenic seizure susceptibility.
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