Abstract
1. Intracellular recordings were made from Retzius neurones in the segmental ganglia of the leech Haemopis sanguisuga. Flourescence, autoradiographic and electron microscopic studies were also undertaken on the Retzius cells.2. Chloride dependent spontaneous ipsps were recorded from Retzius cells. These ipsps and the inhibitory effect of 5-hydroxytryptamine (5-HT) were blocked by morphine. Imipramine potentiated the duration of the 5-HT response.3. Flourescence microscopy demonstrated the presence of 6 5-HT cells in the leech segmental ganglia. These cells specifically take up labelled 5-hydroxytryptophan injected into leeches. Electron microscope studies demonstrated the presence of 1000 Å dense core vesicles in the Retzius cells. Similar dense core vesicles also occur in the ganglion neuropile.4. These results are discussed in terms of further evidence for 5-HT as a the leech segmental ganglia.
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