Abstract
Chemical investigations of the tropical marine sponge Hyrtios sp. have resulted in the isolation of a new alkaloid, 1-carboxy-6-hydroxy-3,4-dihydro-β-carboline ( 1) together with the known metabolites, 6-hydroxy-3,4-dihydro-1-oxo-β-carboline ( 2), 5-hydroxy-1 H-indole-3-carboxylic acid methyl ester ( 3), serotonin ( 4), hyrtiosin A ( 5), 5-hydroxyindole-3-carbaldehyde ( 6), and hyrtiosin B ( 7). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosin B ( 7) displayed a potent inhibitory activity against isocitrate lyase (ICL) of Candida albicans with an IC 50 value of 89.0 μM.
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