Abstract
5-Hydroxyicosatetraenoate (5-HETE) stimulated human neutrophils to elevate their cytosolic Ca 2+. It also enhanced the actions of phorbol myristate acetate and a diacylglycerol in stimulating these cells to: a) translocate protein kinase C from cytosol to membranes; b) generate superoxide anion; and c) release granule-bound enzymes. 5,20-DiHETE and 15-HETE possessed little or none of these bioactions. 5-HETE may influence neutrophil function by elevating cytosolic Ca 2+ and thereby promoting the mobilization of protein kinase C.
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