Abstract
Clozapine and 8-OH-DPAT antagonized haloperidol-induced catalepsy in rats (ED50 10 and 0.1mg/kg s.c., respectively). Whereas the selective 5-HT1A receptor antagonist WAY 100635 (0.1mg/kg s.c.) completely antagonized the inhibitory effect of 8-OH-DPAT, clozapine's effect was not affected. On the other hand, clozapine and 8-OH-DPAT inhibited ultrasonic vocalization in rats (ED50 0.7 and 0.03mg/kg s.c., respectively), which effects were antagonized by WAY 100635. The lack of catalepsy of clozapine, therefore, cannot be addressed primarily to clozapine's agonistic activity at 5-HT1A receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
