Abstract
This is the first [18F]MPPF PET study in positron emission tomography study in depressed patients, both before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Dynamic changes in [18F]MPPF binding potential were observed primarily in the medial orbital regions from baseline to 30days of treatment, suggesting SSRI-mediated serotoninergic adaptative mechanisms.
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