Abstract
A clearer understanding of the role of descending systems in motor control can be achieved by using in vitro preparations of mammalian spinal cord that display patterned motor output, together with the use of selective pharmacological agents. It has been suggested that 5-HT is involved in either the initiation or the modulation of certain motor behaviours, and that it acts to enhance or regulate the motor pattern. Most attention has been paid to the locomotor rhythms underlying walking or swimmig, and in respiratory pattern generation. In this article, David Wallis discusses the involvement of 5-HT 1, and 5-HT 2 receptors in these processes and the possible therapeutic relevance.
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