Abstract
The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance. This review includes the most important part of investigations from the first studies to the latest ones. The established results on the pharmacological activation of 5-HT1A, 5-HT3, 5-HT7 and 5-HT2 receptor types are discussed. Such activation of the first 3 type of receptors causes a decrease in body temperature, whereas the 5-HT2 activation causes its increase. Physiological mechanisms leading to changes in body temperature as a result of 5-HT receptors’ activation are discussed. In case of 5-HT1A receptor, they include an inhibition of shivering and non-shivering thermogenesis, as well simultaneous increase of peripheral blood flow, i.e., the processes of heat production and heat loss. The physiological processes mediated by 5-HT2 receptor are opposite to those of the 5-HT1A receptor. Mechanisms of 5-HT3 and 5-HT7 receptor participation in these processes are yet to be studied in more detail. Some facts indicating that in natural conditions, without pharmacological impact, these 5-HT receptors are important links in the system of temperature homeostasis, are also discussed.
Highlights
Receptors on body temperature in warm-blooded animals and on processes associated with its maintenance
The physiological processes mediated by 5-HT receptor of the type (5-HT2) receptor are opposite to those of the 5-HT receptor of the 1A type (5-HT1A) receptor
Pre-Hypothermic effect of 8-OH-DPAT was attenuated when 5-HT was depleted by repeated i.p. administration of pCPA or by injection of 5,7-DHT into the third ventricle
Summary
Receptors on body temperature in warm-blooded animals and on processes associated with its maintenance. In case of 5-HT1A receptor, they include an inhibition of shivering and non-shivering thermogenesis, as well simultaneous increase of peripheral blood flow, i.e., the processes of heat production and heat loss. “Harmonization” of heat flows escaping the body and coming from outside, led to the occurrence of an important evolutionary acquisition that allowed vertebrates to spread almost throughout the entire territory of our planet, it being the stability of body temperature (homeothermy). This stability is provided by a wonderful physiological system named the system of thermoregulation [2,3]. Being the youngest homeostatic system of the body in evolutionary terms, the system of thermoregulation, when functioning, uses practically all previously formed organs and tissues, including the mediator systems of the brain
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