Abstract
The present study was designed to investigate the nature of the 5-HT 4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT 4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure−threshold pressure) from 19.1±11.8 cm H 2O in the control to 26.8±13.0 cm H 2O ( n=8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT 4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon.
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