Abstract
The effect of a selective 5-HT 1A antagonist, 4-(2′-methoxy-)phenyl-1-[2′-( N-2′′-pyridinyl)- p-iodobenzamino-]ethyl-piperazine (p-MPPI), on acute ethanol-induced hypothermia, sleep and suppression of acoustic startle reflex in C3H/He mice and Wistar rats was studied. Administration of p-MPPI at the doses of 0.4, 0.7 and 1.0 mg/kg reduced in a dose-dependent manner the ethanol-induced hypothermia and the sleep time and attenuated the ethanol-induced decrease of acoustic startle reflex magnitude in mice. Similar p-MPPI (0.4 mg/kg) effects on ethanol-induced sleep and hypothermia were obtained in rats. It was concluded that 5-HT 1A receptors were involved in the mechanisms of the ethanol-induced hypothermia and sleep, and that 5-HT 1A antagonist increased acute ethanol tolerance.
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