Abstract
Ethyl and Butyl Acetate are used as solvents in nail polish, nail polish removers, basecoats, and other manicuring preparations. Ethyl and Butyl Acetate were relatively nontoxic when administered orally, dermally, or by inhalation to rabbits, rats, mice, and guinea pigs. A nail polish containing 10% Ethyl Acetate and 25% Butyl Acetate was a moderate to severe irritant in unrinsed rabbit eyes and a mild irritant in rinsed rabbit eyes. Butyl Acetate was not a sensitizer in either mice or guinea pigs. Ethyl and Butyl Acetate were nonmutagenic when tested by the Ames procedure, Rec-assay, and micronucleus assay. Neither compound induces mitotic aneuploidy in yeast or chromosomal aberrations in Chinese hamster fibroblasts. Butyl Acetate was not teratogenic when inhaled. Ethyl Acetate and Butyl Acetate were mild skin irritants but not sensitizers to humans. Ethyl Acetate was neither phototoxic or photoallergenic in human tests. It is concluded that Ethyl Acetate and Butyl Acetate are safe as cosmetic ingredients in the present practices of use and concentration.
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