Abstract
In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.
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