5 CLINICAL USES OF THE TRH/TSH TEST IN CHILDREN

Abstract

Objetives: Analysis of the hypothalamus-hypophysial axis in 79 children with different patrologies: Retarded growth, Goiter, and G.H. insufficiency, and its relation with thyroid hormones to detect states of subclinical hypothyroidism. Group 1:Retarded Growth:34 children, 12 girls and 22 boys. Mean (X) chroncological age (CA) 8.08±4.25 and 9.14±4.82, respectively. All were under 2SD of the normal range for size according to sex and age. Group 2:Goiter: 31 children, 24 girls and 7 boys. C.A. (X) 10.71±3.51 and 9.86±1.46, respect. The majority of than was submitted to Ant. antithyroid, gamma C and/or thyroid Echog. Group 3:GH insuffic.: 14 children, 10 girls and 4 boys. C.A. (X) 7.90±3.28 and 9.25±2.75, respectively.4 insufficient responses of TSH to TRH were not considered in G.3. No significant differences are observed in basal values. At 30′ X G.2>X G.1 (p<0.01). No significant differences between G.2 and G.3. At 60′ X G.2 and X G.3 > X G.1 (p<0.01) No significant differences between G.2 and G.3. At 90′ X G.3>X G.2 (p< 0.01 X G.2 > X G.1 (p<0.05).