Abstract
In an electron microscope study, it was demonstrated that particles resembling the type C particles had been produced in peripheral leukemic cells or leukocytes obtained from five patients with leukemia and one with reticulum cell sarcoma when these cells had been exposed to 5-bromodeoxyuridine in a short-termed culture. They had electron-dense sphere cores surrounded by a single nuit membrane and varying from 60 to 100nm in outer diameter. Fairly frequently, they appeared in clusters in intracytoplasmic vesicles formed in leukemic myelogenous cells or leukocytes. They were found neither in untreated leukocytes nor in drug-treated lymphocytes or eosinocytes obtained from the patients.Similar electron-dense particles were also demonstrated in peripheral myelogenous leukocytes obtained from three of 10 healthy persons examined after exposure to the drug under the same experimental conditions as mentioned above. No biological activity of these particles was clarified.
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