5-Alkyl-4-amino-2-thiouracilの合成ならびに抗ウイルス性

Abstract

According to the assumption that an antiviral drug against neurotropic viral diseases should possess neurotropy, especially cerebrotropy, hydrophobic alkyl group and hydrophilic amino group was introduced into thiobarbituric acid to form 5-alkyl-4-amino-2-thiouracil and its effect on the Nakayama strain of Japanese B encephalitis virus was examined.As a result, it was found that 5-(2-isobutyl-4-methylpentyl)-4-amino-2-thiouracil and 5-(2-ethyldecyl)-4-amino-2-thiouracil exerted remarkable effect in vivo but not any activity against the virus in vivo.