5,5’-Indigodisulfonic acid as an efficient catalyst for the synthesis of 2,3-dihydroquinazolinone derivatives

Abstract

An efficient protocol for the synthesis of 2,3-dihydroquinazolinone derivatives from substituted 2-aminobenzamides and carbonyl analog catalyzed by the natural-based 5,5’-indigodisulfonic acid has been developed with good to excellent yields. Compared to the reaction conditions reported before, the use of eco-friendly and recyclable catalysts and mild reaction conditions are the major advantages of the present method.