Abstract
The title compound, C11H22NO2 +·I−, is a chiral molecule with five stereogenic centres. The absolute configuration was assigned from the synthesis and confirmed by the structure determination. The central six-membered ring of the indolizine system adopts a chair conformation, with two atoms displaced by −0.690 (2) and 0.550 (2) Å from the plane of the other four atoms. The conformation of the pyrrolidine ring is close to that of an envelope, with the flap atom displaced by 0.563 (2) Å from the plane of the remaining four atoms. In the crystal, there are two O—H⋯I hydrogen bonds.
Highlights
The title compound, C11H22NO2+I, is a chiral molecule with five stereogenic centres
The absolute configuration was assigned from the synthesis and confirmed by the structure determination
Indolizines are important synthetic targets in view of developing new pharmaceuticals for the treatment of cardiovascular diseases (Gubin et al, 1992) and HIV infections (Ruprecht et al, 1989). Based on these facts and in continuation of our interest in developing simple and efficient route for the synthesis of novel indolizine derivatives, we report here the synthesis, molecular and crystal structure of the title compound
Summary
Viktor Vrábel,a* Július Sivý,b Ľubomır Švorc,a Peter Šafářc and Jozefına Žužiovác a Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak. 81237, bInstitute of Mathematics and Physics, Faculty of Mechanical Engineering, Slovak Technical University, Namestie slobody 17, SK-812 31 Bratislava, Slovak. Republic 81231, and cInstitute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic 81237
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