Abstract
Relationship between adipose tissue and fatty liver, and its possible evolution in fibrosis, is supported by clinical and research experience. Given the multifactorial pathogenesis of non-alcoholic fatty liver disease (NAFLD), treatments for various contributory risk factors have been proposed; however, there is no single validated therapy or drug association recommended for all cases which can stand alone. Mechanisms, diagnostics, prevention and treatment of obesity, fatty liver and insulin resistance are displayed along with recommendations and position points. Evidences and practice can get sustainable and cost-benefit valuable outcomes by participatory interventions. These recommendations can be enhanced by comprehensive research projects, addressed to societal issues and innovation, market appeal and industry development, cultural acceptance and sustainability. The basis of participatory medicine is a greater widespread awareness of a condition which is both a disease and an easy documented and inclusive clue for associated diseases and unhealthy lifestyle. This model is suitable for addressing prevention and useful for monitoring improvement, worsening and adherence with non-invasive imaging tools which allow targeted approaches. The latter include health psychology and nutritional and physical exercise prescription expertise disseminated by continuous medical education but, more important, by concrete curricula for training undergraduate and postgraduate students. It is possible and recommended to do it by early formal teaching of ultrasound imaging procedures and of practical lifestyle intervention strategies, including approaches aimed to healthier fashion suggestions. Guidelines and requirements of research project funding calls should be addressed also to NAFLD and allied conditions and should encompass the goal of training by research and the inclusion of participatory medicine topics. A deeper awareness of ethics of competences in health professionals and the articulation of knowledge, expertise and skills of medical doctors, dieticians, health psychologists and sport and physical exercise graduates are the necessary strategy for detectin a suboptimal health status and achieving realistically beneficial lifestyle changes. “The devil has put a penalty on all things we enjoy in life. Either we suffer in health or we suffer in soul or we get fat” (Albert Einstein); the task of medical research and intervention is to make possible to enjoy life also without things that make sufferance in health and souls and which excessively increase body fat.
Highlights
Overview on adipose tissue Ancient bias A good woman had a hen that laid her every day an egg
The road for addressing straight-to-the-point predictive, preventive and personalized medicine in obesity, fatty liver and fibrosis epidemics must take into account the multifactorial pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Numerous treatments for various contributory risk factors have been proposed, but there is no single validated therapy or association recommended for all cases irrespective of the primary NAFLD risk factors
Summary
Overview on adipose tissue Ancient bias A good woman had a hen that laid her every day an egg. Another study showed that mice treated with trans fats in a high-fat diet and high-fructose corn syrup in water, associated to sedentary behaviour, developed a severe phenotype of fatty liver disease with necroinflammatory changes and a profibrogenic response at the molecular level in the setting of obesity, hepatic IR, impaired insulin responsiveness and hyperinsulinemia. Despite all these studies, and many others are available, the road of the search for the benefits, or the disadvantage, of single nutrients, managed as they were drugs, is substantially disappointing, and more realistic approaches address the assessment and the change of nutritional profiles, whose healthy features are defined by epidemiology and by some clinical and experimental evidence [43]. This model is suitable for addressing prevention and useful for monitoring improvement, worsening and adherence with non-invasive imaging tools which allow targeted approaches
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.