4P Prevalence of MET exon 14-mutations or MET amplification in non-small cell lung cancer in Swiss patients

Abstract

Background: MET-targeted treatment has improved by the introduction of highly selective MET inhibitors for advanced stage MET Exon 14-mutated or MET-amplified non-small cell lung cancer (NSCLC). MET exon 14 skipping mutations occur in 3% and MET amplification in 1 to 6% of unselected NSCLC. The aim of our study was to investigate the prevalence of these MET alterations in treatment-naïve pre-selected NSCLC from our routine clinical practice, were MET analyses were generally performed sequentially in NSCLC with high MET expression and wild type status for EGFR, KRAS, ALK and ROS1.