4K – koksyby w codziennej praktyce – komu, kiedy i który?

Abstract

Coxibs, as selective inhibitors of the cyclooxygenase type 2, show a strong analgesic and anti-inflammatory effect. Due to the mechanism of action, there are definitely fewer side effects on the gastrointestinal tract and generally do not require parallel use of proton pump inhibitors. In the light of the latest data, concerns about toxicity to the cardiovascular system are not confirmed. High efficacy and a small amount of side effects make them the preferred drug in patients with previous complications from the gastrointestinal tract, with the risk factors for their occurrence, but also in older people using many other drugs simultaneously.