4-Ethoxymethylene-2-phenyl-5(4H)-oxazolone as a Synthon for the Synthesis of Some Fused Pyrimidines

Abstract

Treatment of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone with nitrogen-containing heterocycles, having amino group in ortho position to the ring nitrogen, leads to the corresponding 4-(arylamino-methylene)-2-phenyl-5(4H)-oxazolones, which can be further converted into different fused pyrimidinones. The (z)-structure of the oxazolone exocyclic double bond has been determined on the basis of 13 C nmr spectroscopy