Abstract

An important way for anti-tumor drug development is using of molecular targets involved in the regulatory pathways during tumorogenesis. As it was found microRNAs (miRs) are active players in this processes. Manipulations with miR-34a and onco-miR-21 demonstrated their effectiveness as antitumor intervention in glioblastoma (GBM), so stable and efficient nanocarriers should be found. One of the promising approach is using of dendrimers – highly symmetrical hyperbranched polymers. The aim of our study was evaluation of effects of treatment by complexes of dendrimers with miRs on human glioblastoma stem-like cells (GSCs).

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