Abstract
Multiple courses of Antenatal Corticosteroids for preterm birth Study (MACS) was an international multi-centered double-blind randomized controlled trial of single vs. multiple courses of antenatal corticosteroids (ACS). Infants exposed to ACS experienced similar composite morbidity and mortality as compared to placebo (12.9 % ACS vs. 12.5% placebo) OR 1.04 (CI 0.77-1.39 p=0.83). Infants in the ACS group were smaller. They weighed less (2216 g vs. 2330 g, p=0.0026), were shorter (44.5 cm vs. 45.4 cm, p=0.001) and had a smaller head circumference (31.1 cm vs.
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