#4905 PERITONEAL CLEARANCE OF TRACE ELEMENTS IN PERITONEAL DIALYSIS PATIENTS

Abstract

Abstract Background and Aims Both accumulations and deficiencies of trace elements (TE) could be seen in peritoneal dialysis (PD) patients. Peritoneal clearance remains major route of elimination for many solutes including TE, in PD patients. Imbalances of TE may have deleterious effects on the patients. Data on TE balances in PD patients are inadequate. Here, we present some data from a larger study. We aimed to analyze peritoneal clearance of Boron (B), Cupper (Cu), Zinc (Zn), Selenium (Se), Strontium (Sr) and Molybdenum (Mo) in a cohort of PD patients. Method This cross-sectional study included three female and five male PD patients giving consent for the study. Mean age was 43,6±5,6 and patients were on continuous ambulatory PD for at least three months. Patients with recent peritonitis were excluded. Peritoneal solutions were individualized, so had different osmolarities. A sample of plasma and 24-hour spent dialysate was analyzed by inductively coupled plasma mass spectrometry (ICP-MS) (Thermo Scientific™ iCAP Q ICP-MS, USA). Sensitivity was on the order of ppb (μg/L). A control group (CG) with glomerular filtration rate ≥ 90 ml/min were used for comparison of plasma levels of TE. Peritoneal clearances were calculated by the following formula: ${{24 \!-\! hour \, spent\, dialysate\, volume \!\times\! \displaystyle\frac{{dialysate\ concentration\ of\ the\ trace\ element}}{{plasma\ concentration\ of\ the\ trace\ element}}}}$ Results Data on plasma levels, clearances and daily loss of TE are shown in the Table 1. The clearances were ordered from smallest to largest as follows: Zn, Cu, Se, Sr, Mo, Ni, B. On the other hand, spent dialysate daily element losses were ordered from smallest to highest as follows: Cr, Ni, Se, Mo, Cu, Sr, Zn, B Conclusion Our study provides data on elimination of some trace elements, which may help to better understand the TE balance in PD patients. Data suggest that B has the highest and Zn the lowest peritoneal clearance values.