Abstract
Publisher Summary This chapter discusses in vivo microdialysis for measurement of extracellular monoamine levels following the inhibition of monoamine transporters. Intracerebral microdialysis is a technique to sample endogenous substances from and to introduce exogenous substances into the brain extracellular fluid by implanting a dialysis fiber in discrete brain areas. Once removed by dialysis from the brain, the endogenous substance is analyzed with various analytic techniques. Various monoamine uptake blockers, which are either selective or nonselective according to the in vitro studies, have been used as tools to explore the in vivo relationship between monoamine transporter function and monoamine neurotransmission. The chapter explains the use of microdialysis to identify the monoamine profile arising from inhibition of monoamine transporters in the ventral tegmental area (VTA)-nucleus accumbens (NAC) DA pathway.
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