Abstract
Foetal erythropoiesis is characterized by many properties of the erythrocytes the best known of which is the presence of haemoglobin F in the erythrocytes. A distinct pattern of hexokinase isoenzymes is a further typical sign of foetal erythrocytes. We have investigated the hexokinase isoenzymes of 4 children (age: 2, 8, 9, and 11 years) with acute myeloid and juvenile chronic myeloid leukaemia, erythroleukaemia and aplastic anaemia whose erythrocytes exhibited in - creased haemoglobin F-concenttrations (8, 65, 53, and 10 %). Their hexokinase isoenzymes were partially purified by treatment with DEAE-Sephadex and separated by analytical isoelectric focussing in polyacrylamide gels. The foetal type of hexokinase isoenzymes was observed in the erythrocytes of all patients. This suggets that the synthesis of haemoglobin F and of the hexokinase isoenzymes are under common control as well in malignancies as in non-malignant disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
