Abstract
Publisher Summary This chapter focuses on a unique means of killing the bacteria in a biofilm and on establishing the physical parameters that produce “total kill.” The work designed to hold the biology constant and vary the current has established a protocol and a test system for investigating the result of adding a dc current flow in conjunction with the antibiotic tobramycin to increase the kill of the bacterium P. aeruginosa that is growing in a biofilm. The dose-response curves and the design of the experimental exposure chambers allow one to estimate the present densities that are needed to reach a desired level of killing. Data that were developed to help define the mechanism of interaction are of equal importance as once again, if one desires to develop a device that will translate these results from the laboratory to a clinical application, the design of the device will depend on an understanding of the means by which the antibiotic efficacy is augmented. There appears to be no doubt that the bioelectric effect can be used to strikingly increase the ability of tobramycin to be effective against P. aeruginosa when the concentration of the antibiotic is about 5 MIC.
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