49 Elevated PTX3 Concentration Is Associated with Primary Graft Dysfunction after Lung Transplantation in Patients with Idiopathic Pulmonary Fibrosis

J.m Diamond ,John M Reynolds ,Joshua R Sonett ,Benjamin Kohl ,Sangeeta Bhorade ,David Weill ,John A Belperio ,Ann Weinacker ,Edward Cantu ,D Wilkes ,C S Deutschman ,S.m Palmer ,Ejigayehu Demissie ,A Shah ,Maria Crespo ,K.m Wille ,V.n Lama ,S.m Kawut ,V.n Ahya ,Pali D Shah ,J Orens ,J Lee ,Selim M Arcasoy ,L.b Ware ,David J Lederer ,J.d Christie

doi:10.1016/j.healun.2011.01.056

49 Elevated PTX3 Concentration Is Associated with Primary Graft Dysfunction after Lung Transplantation in Patients with Idiopathic Pulmonary Fibrosis

J.m Diamond , John M Reynolds + Show 24 more

https://doi.org/10.1016/j.healun.2011.01.056

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Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publication Date: Apr 1, 2011

Affiliation: University of Pennsylvania, Columbia University

#Primary Graft Dysfunction #Primary Graft Dysfunction Pathogenesis + Show 8 more

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Abstract

Primary Graft Dysfunction (PGD) after lung transplantation is the result of ischemia-reperfusion (I-R) injury. Abnormal activation of innate immunity, in response to I-R injury, mediated by Toll-like receptors and interleukin-1 induced long pentraxin-3 (PTX3) release leading to complement activation may play a role in PGD pathogenesis. We hypothesized that elevated PTX3 levels are associated with PGD.

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