Abstract

It is unknown how clinicians’ wording of a treatment influences patients preferences. Decision framing is the way that a choice is worded. A choice can be worded either positively (gain-framed) to explain the benefits of a therapy, or negatively (loss-framed) to explain the risks of not taking a therapy. We conducted a randomized controlled study to evaluate the effect of gain versus loss framing on patients’ treatment preference. Ninety adults with psoriasis ± psoriatic arthritis were randomized 1:1 to receive a questionnaire that contains either (1) a gain-framed message that explains the benefits of receiving an injectable medication for psoriasis and psoriatic arthritis, or (2) a loss-framed message that explains the harms associated with not taking the medication.

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