Abstract
Melanoma is a very heterogeneous neoplasm, with poor chemotherapeutic response. Despite treatment advances, better definition of early molecular steps underlying melanomagenesis is needed. Multiple distinct subpopulations of melanocytes may exist in epidermis, which could explain cutaneous melanoma heterogeneity. Here we assess differentiation and apoptosis status of primary melanocytes (HEM) and melanoma cells (FM3, FM55P, FM55M, SK-MEL-23), after in vitro challenge with UVB irradiation (300 mJ/cm2) for 48h.
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