Abstract
formation (25%). No significant alterations in cholesterol, bile salts or phospholipids were noted demonstrating that this protective effect occurs independently of gallbladder bile lipid concentration. Conclusion: These data demonstrate that IL10 deficiency appreciably and chronically reduces the prevalence of cholesterol gallstones. This protection, at least at the time-point analyzed, appears to be independent of lipid concentration. Because IL10 -/mice displayed significantly reduced gallbladder volumes and mucin gel accumulation, a potential mechanism for this protection is repression of mucin glycoprotein production as well as maintenance of gallbladder wall contractility. These data contrast starkly with other models of chronic gastrointestinal inflammation (i.e., colitis) in which IL10 deficiency promotes disease.
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