Abstract
Squamous cell carcinomas (SCCs) are a group of tumors with shared molecular features across organ types, few targeted treatments, and poorly defined drivers of carcinogenesis. We explored the possibility that alternative RNA splicing is a fundamental mechanism of carcinogenesis across SCC types. Exploiting large scale transcriptional profiling data, we found that splicing profiles significantly differ between SCC and non-SCC cell lines and identified an SCC-specific splicing signature which was characterized by retained intron, exon skipping, and isoform-level events associated with pathways of tumor growth, invasion and metastasis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
