Abstract
The degree of uptake of 18F-fluoro-2-deoxy-glucose (FDG) in NSCLC was consistently shown to be a significant, independent, prognostic factor. Preclinical studies suggest that hypoxic conditions correspond to a higher FDG uptake. Since hypoxia leads to an increased rate of glycolysis, which in turn, increases the uptake of FDG, we hypothesized that the worse prognosis of NSCLC patients with a high FDG uptake would be related to hypoxia. Therefore we investigated the relation between the FDG uptake on PET scan and endogenous immunohistochemical markers of tumor hypoxia (assessed by the expression of Hypoxia Inducible Factor-1α, HIF-1 α, and Carbonic Anhydrase IX, CAIX), tumor proliferation (Ki67) and glucose metabolism (glucose transporters Glut-1 and Glut-3) in NSCLC.
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