Abstract
Background: Some studies have suggested that the patients included in the Z0011 trial may have represented only patients with ultrasound-negative axillary nodes and axillary invasion diagnosed by sentinel node biopsy. Nevertheless, the NCCN guidelines recommend sentinel node mapping if 1 or 2 suspicious lymph nodes are identified on axillary ultrasound. The aim of this preliminary phase of the MUTAS trial was therefore to establish the accuracy of sentinel node mapping in patients with axillary involvement undergoing upfront surgery.
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