48 Increased expression of serum uroplakin III is associated with the detection and pathological features of aggressive bladder cancer

Abstract

the study. No appreciable differences in Gli1 staining were noted by sex, age, smoking status or high risk occupation. Invasive transitional cell carcinoma was less likely to stain for Gli1 than noninvasive tumors in a multivariate analysis (OR 0.61, CI 0.29-1.27), but with limited statistical power. The differences was most evident for Ta compared with T1 tumors (OR 0.38, CI 0.21-0.93) and low grade (grade 1-2) compared with high grade tumors (grade 3) (OR 0.44, CI 0.21-0.93). Gli1 did not affect survival. CONCLUSIONS: Pathogenesis of bladder cancer is complex and not well understood. Our findings indicate a potential role of Gli1 in transitional cell carcinoma differentiation and provide further evidence of effectors of Hedgehog signaling in the molecular pathogenesis of bladder cancer.