Abstract
Oesophageal pH was evaluated over 2 consecutive 24-hour periods in patients with gastrooesophageal reflux disease, before and during acute administration of cisapride. The pH recordings were performed using 2 incorporated distal electrodes, which were placed 5cm above and beyond, respectively, the lower oesophageal sphincter and connected to a solid state portable unit. During the initial 24-hour period 12 patients demonstrated pH recording features compatible with gastro-oesophageal reflux disease and were entered into the second phase of the study, which involved the administration in a double-blind fashion of either cisapride 10mg 3 times daily or placebo. Cisapride administration was associated with a general improvement in all parameters studied, but the changes were statistically significant only at night during clinostatism. The results suggest that cisapride is able to reduce gastro-oesophageal acid reflux in patients with gastrooesophageal reflux disease.
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