47P Inhibition of PD-1 expression by sulconazole through NF-κB repression

Abstract

The overexpression of the immunoinhibitory receptor programmed death-1 (PD1) on T-cells is involved in immune evasion in cancer and reduced clearance of pathogens during chronic infections. Antifungal imidazole derivatives are commonly used for the treatment of topical and systemic infection. The pharmacokinetic dynamics and toxicity of these drugs are now established, suggesting their potential use in other human pathologies treatment including several cancers. Of these Sulconazole (SCZ), is known as ligands of the heme iron atom of the cytochrome P450 (CYP).