479 Distinct patterns of gene expression in skin biopsies differentiate generalized pustular psoriasis (GPP) from psoriasis vulgaris (PV)

Abstract

GPP is a rare, severe, clinically heterogeneous disease characterized by acute, life-threatening flares, and widespread systemic effects. Historically, GPP has been considered a variant of PV; however, evidence indicates that these are distinct diseases, potentially requiring different treatment. We aimed to better understand the differences between GPP and PV by comparing molecular profiles of lesional skin (LS) and nonlesional skin (NLS) from patients with GPP (N=7) or PV (N=17) with skin from healthy volunteers (HV, N=10).