Abstract

RAS/BRAF wt mCRC pts could potentially benefit from antiEGFR treatment but only 50% of them respond. Data from CRCAssigner (CRCA) and Consensus Molecular Subtypes (CMS) classification identified transit-amplifying (TA)/CMS2 as more sensitive to antiEGFR. We aimed to evaluate different gene-expression–based classifiers for identification of RAS wt pts that may benefit from antiEGFR.

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