Abstract
The Wnt/β-catenin signaling pathway plays a key role during embryonic development, homeostasis and cancer. The role of β-catenin in melanocyte lineage establishment and homeostasis has been elucidated, but its role in melanoma remains poorly defined. In particular, its function in cell invasion is controversial. Especially, we generated a signature of β-catenin activation to emerge proteins of interest including known β-catenin target genes (AXIN2, APCDD1, NKD1, SP5, NOTUM, ZNRF3, CCND1 and PPARD) and new genes (SLC1A5, SLC7A11, SLC24A4 and MICAL2).
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