Abstract
Melanoma cells produce a large variety of extracellular vesicles(EVs). Purpose of this study is the evaluation of the diagnostic potential role, like predictive biomarkers of circulating EVs in peripheral blood in patients with primary and metastatic melanoma. The sample was collected by taking a blood sample before surgical removal of lesions suspected of melanoma in order to avoid artifacts due to surgery: overall it was composed of 77 consecutive patients, 12 affected by primary cutaneous melanoma, 8 by metastatic melanoma and 57 healthy controls.
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