475 A retrospective study of myocardial abnormalities detected on cardiac magnetic resonance imaging among patients with psoriasis compared to inflammatory skin disease controls

Abstract

Psoriasis is an inflammatory dermatological disorder that has been associated with various cardiac manifestations. The goal of this study was to evaluate the rates of cardiac inflammation and edema on cardiac MRI in psoriasis patients compared to atopic dermatitis and rosacea control patients so that cardiac magnetic resonance imaging (CMR) can be used as a potential biomarker for psoriasis patients in the future. This was a retrospective chart review that looked at CMR records for markers of cardiac inflammation in adult patients with psoriasis, atopic dermatitis, or rosacea who were patients at The Ohio State University Wexner Medical Center between 2011 and 2018. There were 47 patients with psoriasis and 159 control patients identified. When controlling for BMI and sex, psoriasis patients had higher rates of abnormal T2 septal values (normal = 52.18 ± 3.4) compared to controls (P = 0.0483). This study's findings suggest that psoriasis patients have higher rates of edema and inflammation based on higher rates of abnormal T2 septal values on CMR compared to atopic dermatitis and rosacea controls. The study population was limited by size, as well as by the fact that the psoriasis population used had more males with a higher BMI. More research and prospective CMR mapping in greater numbers of psoriasis patients is necessary to determine the prognostic significance of these abnormalities.