Abstract
Mycosis fungoides (MF) and Sézary syndrome (SS) are classical types of cutaneous T-cell lymphoma (CTCL). MF is the most common type of CTCL, which is characterized by malignant proliferation of neoplastic CD4+ T cells with epidermotropism in the skin. SS is an aggressive leukemic type of CTCL characterized by a triad of erythroderma, lymphadenopathy and leukemic involvement. Squamous cell carcinoma antigen (SCCA) was originally isolated as tumor-specific antigens. SCCA comprises 2 proteins, SCCA1 and SCCA2, and both are induced by type 2 cytokines.
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