Abstract
Objective: Dynamic resistance exercise is recommended for hypertensives. However, blood pressure (BP) increases substantially during its execution due, in part, to peripheral vascular resistance increase. Calcium channel antagonists are commonly used for decreasing peripheral resistance, and consequently BP. This study was designed to test if amlodipine (5 mg) was able to decrease BP absolute levels and BP increase during dynamic resistance exercise performed at low intensity in subjects hypertensives. Design and Methods: The study had a double-blinded cross-over design. Nine 9 essential hypertensives (systolic-SBP/diastolic-DBP between 140/90 and 160/105 mmHg) underwent, in a random order, 4 weeks of placebo and amlodipine treatment, preceded by 2 weeks of any drug washout. At the 4th week of each treatment, the volunteers executed 3 sets of the knee extension exercise to fatigue at 40% of 1RM, with a 90-s rest interval between the sets. Intra-arterial radial BP and heart rate (HR) were measured throughout the protocols. Data was compared by 2-way ANOVA for repeated measures.Conclusion: In conclusion, amlodipine reduced SBP and DBP absolute values achieved during resistance exercise, but didn’t change BP increase during this kind of exercise in hypertensive patients. Financial Support: FAPESP (2009/12572-3) Medication Donation: Medley
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
