472 PREVALENCE, TREATMENT AND CONTROL OF HYPERTENSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

Background: To investigate the prevalence, treatment and control of hypertension in inpatients with CKD from a nationwide, multicenter study in China. Design and Methods: The present study is a cross-sectional survey among a nationwide investigation based on 61 big hospitals of 31 province, municipalities and autonomous regions in China. All demographic, socioeconomic, clinical data and antihypertensive medications were collected by trained physicians using a standardized protocol. Hypertension was defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure 90mmHg, and/or reported hypertension and/or antihypertensive medication use. <130/80mmHg was taken as the threshold blood pressure of hypertensive control. Multivariable logistic regression was used to explore the factors associated inadequate control of hypertension in inpatients with CKD. Results: 10582 eligible participants were analyzed. The prevalence of hypertension was 71.4%, and 87.8% were aware of hypertension diagnosis and 83.7% had been treated with antihypertensive drugs before their hospital admission. 13.9% had controlled blood pressure on the day of admission, and 26.0% had controlled blood pressure on the day before leaving hospital. In hospital, 34.9%, 33.5%, 21.0% and 10.6% used 1, 2, 3 and ≥4 antihypertensive drugs. After multivariable adjusted, CKD4 stage, CKD5 stage, obesity, diabetes, high-salt diet history of smoking, existing hypertension >5 years, and proteinuriawere independently associated with inadequate blood pressure control. Conclusions: The prevalence of hypertension was high, but the control of hypertension was poor in Chinese CKD inpatients. Inadequate combined antihypertensive medication and life-style modification might be the major reasons for suboptimal blood pressure control.