Abstract
Cutaneous field cancerization (FC) is a tissue area chronically exposed to sun light, in which cells present altered cell cycle, proliferation, differentiation, and death despite their normal appearance. On normal sun-exposed skin the most mutated gene is p53 which regulates the expression of p21 which controls cell cycle progression and cellular differentiation. Treatment of cutaneous FC with safe and low-cost molecules could reduce the probability of skin cancer recurrence. Nicotinamide (NAM) is the amide form of vitamin B3, a water-soluble molecule assumed by daily diet.
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