470-P: Elevated NT-ProBNP Is Associated with Significant CT Left Anterior Descending Coronary Artery Calcification Score in T2DM

Abstract

Aims & Objectives: Establish the relationship between N-terminal Pro B-type natriuretic peptide (NT-ProBNP) & CT-Coronary calcium score (CAC) in patients with T2DM. Methodology: Between Oct'19 & Dec'19, 62 asymptomatic T2DM patients, aged 18-75yrs, irrespective of A1c, on regular F/U who had NT-ProBNP ≥ 125pg/ml (Group-G1) & who had undergone CAC & 2D-Echocardiogram (2D) were retrospectively analysed & compared to 62 T2DM patients (Group-G2) with corresponding NT-ProBNP < 125 along with CAC & 2D. Cardio-renal (CR) biomarkers & CAC were compared at the point NT-ProBNP ≥ 125 for Gr-1 with Gr-2. Patients with only preserved ejection fraction (EF) were included. Patients were receiving standard glucose lowering, lipid lowering & BP lowering therapy optimised for CR biomarkers (BMI, HbA1c, Systolic-BP, Diastolic-BP, Lipid profile, highly sensitive C-reactive protein {HSCRP}, Creatinine, urine microalbumin/creatinine ratio {UACR}). Exclusion: low-EF, H/O of IHD, recent (<6mths) hospitalisation &/or coronary intervention. Data analysis: SPSS version 26 & represented as Mean ± 2(SD) with 95% Cl. Pearson co-relation was used & p-value <0.05 was considered significant (S). Results: There was a S difference between Gr-1 & Gr-2 in mean Age yrs (Gr1: 64.35 ± 6.874yrs Vs Gr2: 61.15 ± 6.840, p-0.010), BMI kg/m2 (Gr1: 32.25 ± 5.59 Vs Gr2: 29.66 ± 4.81, p-0.007), NT-ProBNP pg/ml (Gr1: 167.31 ± 159.46 Vs Gr2: 33.98 ± 20.64, p-0.000) & CAC score HU {LAD: Gr1: 286.35 ± 376.83 Vs Gr2: 167.63 ± 234.47, p-0.0393). Total CAC between both groups (Gr1: 471.13 ± 622.81 Vs Gr2: 420.92 ± 659.77, p-0.6638) remained non-significant. There was also no difference seen in SBP, DBP, Lipid Profile (TC, LDL, TG, HDL, Apo B), hs-CRP, serum creatinine, eGFR & UACR. Conclusion: NT-ProBNP ≥125 is related to greater CAC in LAD & may represent an ischemic signal requiring optimal cardiovascular risk factor management inT2DM patients. These patients are older & have a greater BMI. Disclosure V.Gupta: None. V.Teli: None.